What is the role of adamantanes in the treatment of influenza?

Updated: Jan 29, 2019
  • Author: Christian E Sandrock, MD, MPH, FCCP; Chief Editor: Michael Stuart Bronze, MD  more...
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Answer

Answer

Amantadine and rimantadine are antiviral drugs in a class of medications known as adamantanes that were once prescribed for influenza treatment or prophylaxis. These medications are active against influenza A viruses, but not influenza B viruses. In recent past seasons, there has been a high prevalence (>99%) of influenza A(H3N2) and influenza A(H1N1)pdm09 (2009 H1N1) viruses resistant to adamantanes. Therefore, amantadine and rimantadine are not recommended for antiviral treatment or chemoprophylaxis of currently circulating influenza A viruses. [1]


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