Which medications in the drug class Antineoplastics, Alkylating are used in the treatment of Cutaneous Squamous Cell Carcinoma?

Updated: Jul 08, 2020
  • Author: Talib Najjar, DMD, MDS, PhD; Chief Editor: Arlen D Meyers, MD, MBA  more...
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Answer

Antineoplastics, Alkylating

Cisplatin is another chemotherapeutic drug of choice for metastatic cSCC. Although this agent is one of the most successful in the treatment of cancer, it produces major toxicities to normal cells and organs at the concentrations necessary for effective treatment of malignancies.

Cisplatin (Platinol, Platinol AQ, CDDP)

Cisplatin is a platinum coordination compound that inhibits DNA synthesis, cross-links and denatures strands of DNA, and disrupts DNA function by covalently binding to DNA bases. It can also produce DNA intrastrand cross-linking and breakage. It has been used in the treatment of SCC of the head and neck.

Combination chemoradiotherapy using cisplatin and concurrent radiation treatment has improved locoregional control in locally advanced SCC. Chemoradiotherapy is now considered the standard of care in locally advanced disease following surgical resection, as well as in unresectable disease. Cisplatin-based combination chemotherapy with 5-FU, methotrexate, bleomycin, and doxorubicin all have been used to treat advanced SCC, with variable outcomes.

Carboplatin (Paraplatin)

Carboplatin is an analogue of cisplatin. This is a heavy-metal coordination complex that exerts its cytotoxic effect by platination of DNA, a mechanism analogous to alkylation, leading to interstrand and intrastrand DNA cross-links and inhibition of DNA replication. Carboplatin binds to protein and other compounds containing the SH group. It has been used in the treatment of advanced and recurrent head and neck SCC.


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