Which medications in the drug class Antineoplastics, Antimicrotubular are used in the treatment of Cutaneous Squamous Cell Carcinoma?

Updated: Jul 08, 2020
  • Author: Talib Najjar, DMD, MDS, PhD; Chief Editor: Arlen D Meyers, MD, MBA  more...
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Answer

Antineoplastics, Antimicrotubular

Antimicrotubular therapy may be used as part of combination therapy in patients with SCC.

Docetaxel (Taxotere)

Docetaxel is a semisynthetic taxane, a class of drugs that inhibits cancer cell growth by promoting assembly and blocking the disassembly of microtubules, thereby preventing cancer cell division and causing cell death. It is indicated in combination with cisplatin and 5-FU for induction therapy of locally advanced SCC of the head and neck before patients undergo chemoradiotherapy and surgery.

Paclitaxel

Paclitaxel is an antimicrotubule agent. Its mechanism of action includes tubulin polymerization and microtubule stabilization, which, in turn, inhibit mitosis and may result in breakage of chromosomes. It is used off-label in SCC of the head and neck.


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