What are the treatment options of squamous cell carcinoma in situ (SCCIS)?

Updated: Jul 08, 2020
  • Author: Talib Najjar, DMD, MDS, PhD; Chief Editor: Arlen D Meyers, MD, MBA  more...
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Several effective treatment modalities exist for precancerous skin lesions, including squamous cell carcinoma in situ (SCCIS) and actinic keratosis. Most of these treatments are easily performed in an outpatient setting.

Topical application of 5-FU or imiquimod is effective in treating precancerous skin lesions. Similarly, liquid nitrogen cryotherapy or electrocautery and curettage may be used, with cure rates reported at greater than 95%. The risks associated with cryotherapy include transient pain, edema, and blistering. Hypopigmentation and alopecia are also common and may be permanent, so treatment of hair-bearing areas and in darkly pigmented individuals is generally not recommended. [67]

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