How is conjunctival intraepithelial neoplasia treated?

Updated: Jul 08, 2020
  • Author: Talib Najjar, DMD, MDS, PhD; Chief Editor: Arlen D Meyers, MD, MBA  more...
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Answer

Topical cytotoxic therapy (ie, 5-FU, mitomycin C [MMC]) has been used to treat conjunctival intraepithelial neoplasia and to debulk large carcinomas before surgical excision. Orbital invasion may be observed despite topical therapy, however, and careful monitoring of patients on these agents is warranted. [55, 56]

Despite its significant potential for deleterious effects on limbal stem cells, mitomycin C 0.04% is effective as a neoadjuvant or postoperative agent in the treatment of conjunctival intraepithelial neoplasia and primary acquired melanosis. Its utility is less well proven for truly invasive tumors, such as melanoma and carcinoma. [57]


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