What is the role of adjuvant chemotherapy in the treatment of cutaneous squamous cell carcinoma (cSCC)?

Updated: Jul 08, 2020
  • Author: Talib Najjar, DMD, MDS, PhD; Chief Editor: Arlen D Meyers, MD, MBA  more...
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Adjuvant medication may be considered in select highest-risk cases of cSCC. Options include oral 5-fluorouracil (5-FU) and epidermal growth factor receptor (EGFR) inhibitors. Treatment should be administered through oncology treatment centers. Although survival data are lacking, these medications are generally well tolerated, with few adverse effects.

One study found that the use of topical 5-FU 1% is effective as an adjuvant to surgical excision in treating patients with localized ocular surface squamous neoplasia. Although frequent short-term complications were noted, a low rate of local recurrence was found; a full course is usually tolerated, and serious complications in the study were uncommon. [48]

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