What is the role of Mohs micrographic surgery in the treatment of cutaneous squamous cell carcinoma (cSCC)?

Updated: Jul 08, 2020
  • Author: Talib Najjar, DMD, MDS, PhD; Chief Editor: Arlen D Meyers, MD, MBA  more...
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Mohs micrographic surgery is a specialized technique for removing many forms of skin cancer, including cSCC. Because of its numerous advantages, Mohs micrographic surgery is the procedure of choice in the following situations:

  • SCC in which tissue preservation is needed

  • Ill-defined SCC

  • Recurrent tumors

  • High-risk SCC

Mohs surgery, which was developed by Frederic E. Mohs in the 1930s, is a method of tumor excision in which the surgeon first excises the visible tumor with a small margin of normal tissue. Horizontal frozen sections are then prepared, and the entire margin is evaluated under the microscope. Areas that demonstrate residual microscopic tumor involvement are re-excised, and the margins are reexamined. This cycle is completed until no further tumor is visualized. [46]

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