Which conditions should be included in the differential diagnoses of cutaneous squamous cell carcinoma (SCC)?

Updated: Jul 08, 2020
  • Author: Talib Najjar, DMD, MDS, PhD; Chief Editor: Arlen D Meyers, MD, MBA  more...
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Other conditions to be considered

The following conditions should also be considered when evaluating a patient with suspected SCC:

  • Cancerous lesions: Sebaceous cell carcinoma and rhabdomyosarcoma

  • Congenital tumors: Dermoids, dermolipomas, and episcleral osseous choristoma

  • Conjunctival degeneration: Pinguecula and amyloidosis

  • Hereditary lesions: Benign hereditary intraepithelial dyskeratosis

  • Lymphoid tumors: Lymphoid neoplasia, benign reactive lymphoid hyperplasia, and leukemic infiltrates

  • Neuroectodermal tumors: Nevus, primary acquired melanosis, and melanoma

  • Papillomas: Human papillomavirus (HPV) ̶ induced papillomas

  • Pseudocancerous lesions: Pseudoepitheliomatous hyperplasia and keratoacanthoma

  • Vascular lesions: Angioma, lymphangioma, Kaposi sarcoma, and pyogenic granuloma

  • Xanthomatous lesions: Juvenile xanthogranuloma and fibrous xanthoma

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