What is the prevalence of perineural invasion in patients with cutaneous squamous cell carcinoma (cSCC)?

Updated: Jul 08, 2020
  • Author: Talib Najjar, DMD, MDS, PhD; Chief Editor: Arlen D Meyers, MD, MBA  more...
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Up to 14% of cSCCs exhibit perineural invasion. Evidence of cranial nerve dysfunction on examination should raise concern of significant perineural invasion. The most frequently involved cranial nerves are the facial and trigeminal nerves, [37] underscoring the importance of assessment of facial movement and sensation. Therefore, every patient with head and neck cSCC should undergo systematic evaluation of cranial nerve function.

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