How does cellular differentiation affect the prognosis of squamous cell carcinoma (SCC)?

Updated: Jul 08, 2020
  • Author: Talib Najjar, DMD, MDS, PhD; Chief Editor: Arlen D Meyers, MD, MBA  more...
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More poorly differentiated tumors have a worse prognosis in SCC, with reported recurrence rates of 33-54%. [33] The actual value of histologic grading alone, however, is less clear, because poorly differentiated tumors that metastasize or recur usually have additional primary risk factors (eg, large diameter, greater depth). Nonetheless, poorly differentiated lesions are generally considered to behave more aggressively.

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