How does the diameter and thickness of lesions affect the prognosis of invasive squamous cell carcinoma (SCC)?

Updated: Jul 08, 2020
  • Author: Talib Najjar, DMD, MDS, PhD; Chief Editor: Arlen D Meyers, MD, MBA  more...
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Lesions of invasive SCC measuring smaller than 2 cm in diameter have been associated with a 9.1% rate of metastasis, whereas those larger than 2 cm in diameter have a metastatic rate of up to 30.3%. A prospective study reported a 3-year, disease-specific survival rate of 67% for lesions larger than 4 cm, compared with 93% for tumors smaller than 4 cm. [31]

A study by Eigentler et al indicated that in cases of cSCC, factors contributing to a high risk for tumor-specific death, if a cut-off for tumor thickness of 6 mm or greater is used, include desmoplastic growth and immunosuppression. [32]

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