What is the global incidence of cutaneous squamous cell carcinoma (cSCC)?

Updated: Jul 08, 2020
  • Author: Talib Najjar, DMD, MDS, PhD; Chief Editor: Arlen D Meyers, MD, MBA  more...
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Despite increased knowledge and public education regarding the causes of skin cancer and the importance of avoiding prolonged sun exposure, the incidence of cSCC continues to rise worldwide. A study from South Korea looking at skin cancer incidences between 1999 and 2014 found that the incidence of SCC in that country rose steadily in those years, with the average annual percentage change in men and women being 3.3 and 6.8, respectively. [24] In Rochester, Minnesota, the annual age-adjusted incidence rates for SCC per 100,000 women rose from 47 cases from 1984-1986 to 100 cases from 1990-1992; the corresponding rates for men increased from 126 cases to 191 cases per 100,000 population. [25]

This increasing incidence is likely multifactorial; speculated causes include an aging population, improved detection, increased use of tanning beds, and environmental factors, such as depletion of the ozone layer.

Additionally, the number of patients on immunosuppressive therapy, used in solid organ transplantation and various rheumatologic and dermatologic conditions, is increasing. As noted previously, solid organ transplant recipients have a markedly elevated risk of SCC formation. Metastasis may also be more common in this group.

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