What are treatment options for cutaneous squamous cell carcinoma (cSCC)?

Updated: Jul 08, 2020
  • Author: Talib Najjar, DMD, MDS, PhD; Chief Editor: Arlen D Meyers, MD, MBA  more...
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Treatment options include the following:

  • Surgical excision with clear margins, as verified by frozen sections

  • Mohs micrographic surgery for invasive cSCC in the facial region

  • Radiation therapy as an adjuvant to surgery, to provide improved locoregional control, or as primary therapy in patients who are unable to undergo surgical excision

  • Chemotherapy, such as treatment with oral 5-fluorouracil (5-FU) and epidermal growth factor receptor (EGFR) inhibitors, as adjuvant therapy for select highest-risk cases

  • Systemic chemotherapy for metastatic cSCC

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