What is the efficacy of pedunculopontine nucleus deep brain stimulation (DBS) in the treatment of Parkinson disease (PD)?

Updated: Dec 09, 2020
  • Author: Konstantin V Slavin, MD; Chief Editor: Brian H Kopell, MD  more...
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Pedunculopontine nucleus DBS (PPN DBS) is a promising approach to treat patients with PD, particularly medication-refractory gait freezing and falls. [44] However, PPN DBS is still under the phase of investigation. The clinical data showed that gait freezing and falls can be improved by PPN DBS. [44] However, it is unclear whether PPN DBS can improve quality of life in patients with PD. Moreover, a collaborative effort is required to confirm whether PPN DBS is a reliable therapy for PD or not. [44]

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