What is the role of lab studies in the workup of anal fissure?

Updated: Nov 28, 2018
  • Author: Lisa Susan Poritz, MD; Chief Editor: John Geibel, MD, DSc, MSc, AGAF  more...
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If an ordinary anal fissure is suggested and if it is located in the posterior or anterior midline, then no laboratory tests are necessary.

If the fissure is off the midline or irregular, or if an underlying illness (eg, Crohn disease, squamous cell cancer, or AIDS [4] ) may be present, then the appropriate tests should be ordered; these may include the following:

  • Erythrocyte sedimentation rate (ESR)
  • Stool and viral cultures
  • HIV testing
  • Biopsy of the lesion or fissure (as warranted)

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