Which conditions are included in the differential diagnoses of sickle cell nephropathy (SCN)?

Updated: Sep 12, 2019
  • Author: Phuong-Thu Pham, MD, FASN; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Answer

Answer

Prior to confirming a diagnosis of SCN, other causes of renal dysfunction should be ruled out, including the following:

  • Recent or current use of nephrotoxic medications
  • Acute tubular necrosis secondary to hemodynamic perturbations from other causes
  • Hematuria secondary to nephrolithiasis, urinary tract tumors, or coagulopathies
  • Acute edema or proteinuria secondary to other glomerular disease processes (active urine sediments suggest pathology other than SCN), membranoproliferative glomerulonephritis (MPGN) associated with hepatitis C virus infection, membranous glomerulopathy associated with chronic hepatitis B infection, or renal vein thrombosis
  • Papillary necrosis from disorders such as diabetic nephropathy, analgesic-abuse nephropathy, or chronic tubulointerstitial nephritis
  • Postrenal failure secondary to obstruction from papillary necrosis or nephrolithiasis

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