What is the relationship between proteinuria and sickle cell disease (SCD)?

Updated: Sep 12, 2019
  • Author: Phuong-Thu Pham, MD, FASN; Chief Editor: Vecihi Batuman, MD, FASN  more...
  • Print


In individuals with SCD, the prevalence of albuminuria and proteinuria is 30% within the first 3 decades of life and increases up to 70% in older patients. A  study of 101 Yemeni children with SCD, aged 1–16 years, the overall prevalence of microalbuminuria was 30.7%, with male predominance (80.6%);  the mean age of children with microalbuminuria was 7.5 ± 3.2 years, and 10% of them were under 5 years of age. [24]  

Albuminuria or overt proteinuria often precedes the elevation of creatinine. The development of nephrotic syndrome has been linked to progression to renal failure. [1] Proteinuria may be associated with defects in glomerular permselectivity, tubular injury, and/or specific single nucleotide polymorphisms in the MYH9 and APOL1 genes. [6, 18]

Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!