How is invasive lobular carcinoma differentiated from invasive ductal carcinoma?

Updated: May 24, 2018
  • Author: Peter Abdelmessieh, DO, MSc; Chief Editor: Marie Catherine Lee, MD, FACS  more...
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Answer

Answer

Staining for E-cadherin can add in distinguishing lobular carcinoma from invasive ductal carcinoma. Studies have illustrated a link between cadherin (CDH1) gene and invasive lobular breast cancers, with approximately 50 % of this subtype of breast cancer containing E-cadherin mutations. However, like ductal carcinoma, infiltrating lobular carcinoma typically metastasizes to axillary lymph nodes first. However, it also has a tendency to be more multifocal. Despite that, the prognosis is comparable to that of ductal carcinoma. [1]


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