What is the role of BTA STAT & TRAK tests in the diagnosis of bladder cancer?

Updated: Nov 01, 2018
  • Author: Gary David Steinberg, MD, FACS; Chief Editor: Bradley Fields Schwartz, DO, FACS  more...
  • Print
Answer

Answer

The BTA STAT & TRAK tests (Polymedco; Cortlandt Manor, NY) use monoclonal antibodies to detect complement factor H-related protein and complement factor H in voided urine specimens. These factors are found in bladder cancer cell lines and inhibit the complement cascade to prevent cell lysis.BTA STAT is a point of care qualitative assay with an average sensitivity and specificity of 68.7% (53-89%) and 73.7% (54-93%), respectively.BTA TRAK is a quantitative enzyme-linked immunosorbent assay with similar sensitivity and specificity of 62% (17-78%) and 73.6% (51-95%), respectively. [22] Studies have shown wide ranges of sensitivity and specificity with BTA testing. Additionally, the specificity of both of these tests can be significantly decreased, as false positives have been noted to occur in the setting of hematuria, urolithiasis, inflammation, recent instrumentation, other genitourinary malignancies, and intravesical BCG therapy. [23]


Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!