What is the role of a FISH assay in the diagnosis of bladder cancer?

Updated: Nov 01, 2018
  • Author: Gary David Steinberg, MD, FACS; Chief Editor: Bradley Fields Schwartz, DO, FACS  more...
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Answer

Answer

A commercial FISH assay (UroVysion Bladder Cancer Kit, Abbott Molecular; DesPlaines, Ill), which includes probes for the centromeres for chromosomes 3, 7, and 17 and has a locus-specific probe for 9p21, was developed to screen for recurrent urothelial carcinoma and was approved by the US Food and Drug Administration (FDA) in 2005. The intended use is as an aid for initial diagnosis of bladder cancer in patients with hematuria and subsequent monitoring for tumor recurrence in patients previously diagnosed with bladder cancer. Positive findings on FISH often precede visual evidence of bladder tumor.


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