Which urinary biomarkers are used in the diagnosis of bladder cancer?

Updated: Nov 01, 2018
  • Author: Gary David Steinberg, MD, FACS; Chief Editor: Bradley Fields Schwartz, DO, FACS  more...
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More than 30 urinary biomarkers have been reported for use in bladder cancer diagnosis, but only a few are commercially available; the remainder are still being tested. [1, 2]  In addition to urine cytology, commercially available tests include the following:

  • Fluorescence in situ hybridization (FISH) probe set (UroVysion)
  • Nuclear matrix protein (NMP-22)
  • BTA stat
  • Fluorescent monoclonal antibodies against M344, LDQ10, and 19A211 (ImmunoCyt/uCyt+) 
  • Multiplex immunoassays (CertNDx)
  • Reverse transcription quantitative polymerase chain reaction  (CxBladder)

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