How is endemic syphilis differentiated form venereal syphilis, yaws, and pinta?

Updated: Sep 14, 2020
  • Author: Hassan I Galadari, MD; Chief Editor: Dirk M Elston, MD  more...
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Because of the overlap between treponematoses, endemic syphilis has to be correctly differentiated from venereal syphilis, yaws, and pinta. The differential diagnoses of the diseases are very similar, and some features, such as nasopharyngeal lesions, can be difficult to differentiate.

During the early stages, features in endemic syphilis resemble a number of dermatoses, mainly eczema, mycoses, psoriasis, leprosy, herpes simplex, perlèche, and condylomata acuminata.

In the late stages, the features overlap those of malignant tumors, including carcinoma; mycosis fungoides; lupus vulgaris; and lupus erythematosus. [13]

The mutilating nasopharyngeal lesions can be mistaken for tertiary venereal syphilis tuberculosis, leprosy, rhinoscleroma, and mucocutaneous leishmaniasis.

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