What are the signs and symptoms of late-stage endemic syphilis?

Updated: Sep 14, 2020
  • Author: Hassan I Galadari, MD; Chief Editor: Dirk M Elston, MD  more...
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The development of tertiary and late-stage disease usually occurs 6 months to years after inoculation.

Destruction of the bone and the cartilage in the formation of gummatous lesions (commonly in the nose) may take place. The gummas can ulcerate and develop chronic serpiginous tracts. Healing results in depigmented scars with a hyperpigmented border.

Saddle nose deformity and palate perforation can occur.

Rare, atypical involvement of the cardiovascular and nervous systems can occur.

See the image below.

Third-stage gummatous lesions. Third-stage gummatous lesions.

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