What are the signs and symptoms of secondary-stage endemic syphilis?

Updated: Sep 14, 2020
  • Author: Hassan I Galadari, MD; Chief Editor: Dirk M Elston, MD  more...
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This stage usually consists of macerated, eroded patches on the lips, the tongue, and the tonsils. Hypertrophic condyloma lata can appear in the anogenital area.

Nontender, generalized lymphadenopathy is common, painful osteoperiostitis in the long bones (eg, tibia) can occur, and angular stomatitis resembling that caused by vitamin B deficiency can be seen.

The secondary stage can persist for 6-9 months.

See the image below.

Second-stage condylomata lata lesions. Second-stage condylomata lata lesions.

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