What are the signs and symptoms of cryptococcal meningitis in patients with HIV infection?

Updated: Aug 24, 2017
  • Author: Gulshan Uppal, MD; Chief Editor: Niranjan N Singh, MBBS, MD, DM, FAHS, FAANEM  more...
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Answer

Answer

Cryptococcal meningitis can occur acutely, with severe headache, change in mental status, fever, nuchal rigidity, and focal signs, or with a subacute course of malaise and headache without stiff neck over several weeks.

Surprisingly, a study from China published in 2012 found a lower mortality in HIV-infected patients than in HIV-uninfected patients with cryptococcal meningitis. [2] The reason for decreased mortality in the HIV-infected population was determined to be low intensity of inflammation and effective surgical cerebrospinal fluid drainage for increased intracranial pressure.


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