Which intravesical chemotherapeutic agents are used in the treatment of bladder carcinoma in situ?

Updated: Oct 24, 2019
  • Author: Stanley A Brosman, MD; Chief Editor: Bradley Fields Schwartz, DO, FACS  more...
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Answer

Answer

Chemotherapeutic agents that can be administered intravesically to treat carcinoma in situ (CIS) include the following:

  • Mitomycin-C

  • Gemcitabine

  • Doxorubicin

  • Valrubicin

  • Thiotepa

  • Cisplatin

No evidence suggests that these adjuvant therapies are as effective as bacillus Calmette-Guérin (BCG). These agents may increase the time to disease recurrence, but no evidence indicates that they prevent disease progression.


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