How is squamous cell carcinoma (SCC) graded?

Updated: Jan 24, 2019
  • Author: Muhammad T Idrees, MD; Chief Editor: Liang Cheng, MD  more...
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Answer

Answer

The squamous cell tumor is generally graded as well differentiated, moderately differentiated, or poorly differentiated, depending on the extent of keratinization and nuclear pleomorphism. [18, 48, 49, 50] However, the grading system is not universally reproducible, as some authors believe that there is no direct correlation between the aggressiveness and the tumor grade. [18] Others believe that histologic grade influences the tumor stage and clinical outcome. [48, 49]  A 2019 propensity analysis of National Cancer Database bladder cancer data (2004-2013) from 3332 patients found that histology had a larger impact on survival than tumor stage. [1]  Nuclear tetraploidy and aneuploidy correlate with the grade and stage of squamous cell carcinoma and adversely affect survival. [50, 51]


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