What is the role of immunohistochemistry in the diagnosis of squamous cell carcinoma (SCC)?

Updated: Jan 24, 2019
  • Author: Muhammad T Idrees, MD; Chief Editor: Liang Cheng, MD  more...
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Answer

Answer

The diagnosis of squamous cell carcinoma of the bladder is primarily based on the morphology. The immunohistochemical stains do not have a substantial role in diagnosing this tumor. CK20 has been seen in the majority of cases of urothelial carcinoma; however, in one study, none of the schistosomal-associated squamous cell carcinomas stained. COX-2 and uroplakin II expression has not been observed in any of the squamous cell carcinomas of the bladder, but they have been expressed in the majority of urothelial carcinomas. [27, 28]


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