What is basaloid squamous cell carcinoma (SCC)?

Updated: Jan 23, 2019
  • Author: Muhammad T Idrees, MD; Chief Editor: Liang Cheng, MD  more...
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A single case of basaloid squamous cell carcinoma of the bladder was reported in a 60-year-old woman with incontinence, intractable urinary tract infections (UTIs), and flat, cystoscopic lesions. [25] Microscopically, the tumor was composed of nests of basaloid cells with numerous mitoses, areas of squamous differentiation, and squamous cell carcinoma in situ. Bostwick and Cheng proposed that the correct terminology should be urothelial carcinoma with basaloid features, rather than basaloid squamous cell carcinoma. [26]

Basaloid squamous cell carcinoma of the bladder has also been reported with small-cell carcinoma. [20]  A 54-year-old male had multiple sclerosis-related neurogenic bladder and chronic UTIs. Histologic findings of a cystoscopic speciment from a large right-bladder tumor was consistent with basaloid squamous cell carcinoma, with invasion of the muscular layer and vascular invasion; histopathologic features from a radical cistectomy specimen confirmed these findings as well as revealed squamous metaplasia, squamous carcinoma in situ, and a 5% small-cell carcinoma feature. [20]

HPV infection also appears have an association with basaloid squamous cell carcinoma of the bladder in the setting of neurogenic bladder, with at least four cases reported. [9, 10, 11]

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