What is squamous cell carcinoma (SCC)?

Updated: Jan 23, 2019
  • Author: Muhammad T Idrees, MD; Chief Editor: Liang Cheng, MD  more...
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Squamous cell carcinoma (SCC) is the second most common cell type associated with bladder cancer in developed countries (urothelial carcinoma is the most common type of bladder cancer [about 90%]), [1, 2] accounting for 2%-5% of bladder neoplasms. [3]  In the United States, an estimated 1%-2% of bladder cancers are squamous cell carcinomas, [2, 4]  often associated with spinal cord injury and with the long-term use of an indwelling catheter. [3]  Worldwide, however, squamous cell carcinoma is the most common form of bladder cancer, accounting for up to 73% of cases in developing nations, particularly regions with a high prevalence of schistosomiasis (eg, Middle East, Southeast Asia, South America). [5, 6]  Human papillomavirus infection also appears to have an association with squamous cell bladder carcinoma. [7, 8, 9, 10, 11]

Squamous cell carcinoma of the bladder is an aggressive, commonly invasive, disease that generally presents at a more advanced stage than urothelial carcinoma. [3, 4, 12, 13]

For more information, see Bladder Cancer, as well as Pathologic Findings in Small Cell Bladder Carcinoma and Cystoscopy.

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