Which findings on genetic analysis are characteristic of small cell bladder carcinoma?

Updated: Jun 06, 2019
  • Author: Zhong Jiang, MD; Chief Editor: Liang Cheng, MD  more...
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Answer

Answer

As in small cell carcinoma of other organs, that of the bladder tumor cell exhibits abundant genomic aberrations. Typically, every tumor cell has more than 10 in number. The most frequent changes include deletions of 10q, 4q, 5q, and 13q and gains of 8q, 5p, 6p, and 20q. It is also suggested that acquisitions of genomic alterations in typical invasive urothelial carcinoma lead to the development of small cell bladder carcinoma. Genomic DNA amplifications are also found in many loci where oncogenes are located. [13]

More recent investigations indicate that patterns of gene expression in small cell bladder carcinoma are associated with distinct clinical phenotypes (ie, from more indolent to aggressive disease). [14] Overexpression of DLL3 mRNA and protein frequently occurs and correlates with shorter overall survival.


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