Which microscopic findings are characteristic of small cell bladder carcinoma?

Updated: Jun 06, 2019
  • Author: Zhong Jiang, MD; Chief Editor: Liang Cheng, MD  more...
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Answer

Answer

Sixty-eight percent of small cell carcinoma of the urinary bladder cases are mixed with classic urothelial carcinomas or adenocarcinomas of the bladder. [9] The histologic features of small cell carcinoma are the same as those in other organs. The tumor is made of sheets and nests of loosely cohesive, small, round or oval cells with very scant cytoplasm (see the image below).

Small cell carcinoma of the bladder. The tumor is Small cell carcinoma of the bladder. The tumor is made of sheets and nests of loosely cohesive, small, round or oval cells with very scant cytoplasm.

The tumor cell nuclei are hyperchromatic with coarsely granular chromatin. Nuclei molding can be seen. Mitosis is present and may be frequent. Nucleoli are absent or small. Tumor necrosis is often present. Urinary cytology often reveals single and loosely cohesive clusters of tumor cells with typical small cell carcinoma morphology.


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