What are the age predilections of torsade de pointes?

Updated: Jan 31, 2017
  • Author: Jatin Dave, MD, MPH; Chief Editor: Mikhael F El-Chami, MD  more...
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Answer

Answer

Torsade occurs in patients of a wide age range, from newborns to the very elderly. The highest frequency is in patients aged 35-50 years. Torsade that occurs at an early age usually is due to congenital long QT syndrome. In older persons, it usually is due to acquired long QT syndrome. In a systematic review, investigators found that slightly over half (50.8%) of elderly patients (age ≥80 years) with drug-induced torsade experienced it as the result of "reckless administration" of a QT-interval prolonging agent. [16] The most common occurrences of reckless administration of a QT-interval prolonging were in conjunction with another such agent (51.6%) or despite a known QT-interval prolongation (25.8%). [16]


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