What is the role of C-reactive protein (CRP in the etiology of noncoronary atherosclerosis?

Updated: Dec 23, 2019
  • Author: F Brian Boudi, MD, FACP; Chief Editor: Yasmine S Ali, MD, FACC, FACP, MSCI  more...
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Answer

Answer

In a cohort of healthy men, baseline C-reactive protein (CRP) levels were found to be predictive of symptomatic peripheral vascular disease. CRP reflects systemic inflammation, and these results support the hypothesis that chronic inflammation may play a role in the pathogenesis and progression of atherosclerosis.

Standardization of the CRP assay is required before this test may be clinically useful, and whether CRP levels are a truly modifiable risk factor remains unclear.


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