What is the role of DNA (deoxyribonucleic acid) cytometry in the workup of borderline ovarian cancer?

Updated: Mar 18, 2019
  • Author: Andrew E Green, MD; Chief Editor: Warner K Huh, MD  more...
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Answer

Answer

Although not routine, static DNA cytometry can be performed on biopsy specimens. As previously stated, about 95% of borderline ovarian tumors have diploid DNA, which is almost always associated with an excellent prognosis.

With the advent of microarray technology, the characterization of the tumor genome can now be studied. Some preliminary work concerning the invasive forms of ovarian cancer is starting to emerge. However, little has been done on borderline ovarian cancer, mostly because of its low incidence and good prognosis.

Some data suggest that invasive tumors discovered at low stages and borderline tumors, especially those with invasive implants, share genetic expression profiles. However, the significance of this has not been determined.


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