What causes borderline ovarian cancer?

Updated: Mar 18, 2019
  • Author: Andrew E Green, MD; Chief Editor: Warner K Huh, MD  more...
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The etiology of this disease remains unclear because of the small number of cases and the lack of randomized, controlled studies. Based on molecular studies, some mucinous borderline tumors of the ovary may actually represent metastasis from the appendix.

Although none of these has been shown to be statistically significant, factors reportedly linked with borderline tumors include the following:

  • Oral contraceptive use

  • Menarche

  • Age at first pregnancy

  • Age at first delivery

  • Menstrual history

  • Smoking history

  • Family history of ovarian cancer

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