What are the prognostic stages for breast cancer?

Updated: Dec 27, 2019
  • Author: Pavani Chalasani, MD, MPH; Chief Editor: John V Kiluk, MD, FACS  more...
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Answer

Table 5. Histologic grade (Open Table in a new window)

Histologic grade (G)

GX

Grade cannot be assessed

G1

Low combined histologic grade (favorable)

G2

Intermediate combined histologic grade (moderately favorable)

G3

High combined histologic grade (unfavorable)

Table 6. Anatomic stage/prognostic groups (Open Table in a new window)

Stage

T

N

M

0

Tis

N0

M0

IA

T1

N0

M0

IB

T0

N1mi

M0

 

T1

N1mi

M0

IIA

T0

N1

M0

 

T1

N1

M0

 

T2

N0

M0

IIB

T2

N1

M0

 

T3

N0

M0

IIIA

T0

N2

M0

 

T1

N2

M0

 

T2

N2

M0

 

T3

N1

M0

 

T3

N2

M0

IIIB

T4

N0

M0

 

T4

N1

M0

 

T4

N2

M0

IIIC

Any T

N3

M0

IV

Any T

Any N

M1

Notes:

  • T1 includes T1mi.
  • T0 and T1 tumors with nodal micrometastases (N1mi) are staged as Stage IB.
  • T2, T3, and T4 tumors with nodal micrometastases (N1mi) are staged using the N1 category.
  • M0 includes M0(i+)
  • The designation pM0 is not valid; any M0 is clinical.
  • If a patient presents with M1 disease prior to neoadjuvant systemic therapy, the stage is considered stage IV and remains stage IV regardless of response to neoadjuvant therapy.
  • Stage designation may be changed if postsurgical imaging studies reveal the presence of distant metastases, provided the studies are performed within 4 months of diagnosis in the absence of disease progression, and provided the patient has not received neoadjuvant therapy.
  • Staging following neoadjuvant therapy is designated with “yc” or “yp” prefix to the T and N classification. No anatomic stage group is assigned if there is a complete pathologic response (pCR) to neoadjuvant therapy, for example, ypT0ypN0cM0.

Table 7. Clinical prognostic stage (Open Table in a new window)

TNM

Grade

HER2

ER

PR

Stage

Tis N0 M0

Any

Any

Any

Any

0

T1 N0 M0

T0 N1mi M0

T1 N1mi M0

G1

Positive

Positive

Positive

IA

Negative

Negative

Positive

Negative

Negative

Positive

Positive

Negative

Negative

Positive

Negative

IB

G2

Positive

Positive

Positive

IA

Negative

Negative

Positive

Negative

Negative

Positive

Positive

Negative

Negative

Positive

Negative

IB

G3

Positive

Positive

Positive

IA

Negative

Negative

Positive

Negative

Negative

Positive

Positive

Negative

IB

Negative

Positive

Negative

T0 N1 M0

T1 N1 M0

T2 N0 M0

G1

Positive

Positive

Positive

IB

Negative

IIA

Negative

Positive

Negative

Negative

Positive

Positive

IB

Negative

IIA

Negative

Positive

Negative

G2

Positive

Positive

Positive

IB

Negative

IIA

Negative

Positive

Negative

Negative

Positive

Positive

IB

Negative

IIA

Negative

Positive

Negative

IIB

G3

Positive

Positive

Positive

IB

IIA

Negative

Negative

Positive

Negative

Negative

Positive

Positive

Negative

IIB

Negative

Positive

Negative

T2 N1 M0

T3 N0 M0

G1

Positive

Positive

Positive

IB

Negative

IIA

Negative

Positive

Negative

IIB

Negative

Positive

Positive

IIA

Negative

IIB

Negative

Positive

Negative

G2

Positive

Positive

Positive

IB

Negative

IIA

Negative

Positive

Negative

IIB

Negative

Positive

Positive

IIA

Negative

IIB

Negative

Positive

Negative

IIIB

G3

Positive

Positive

Positive

IB

Negative

IIB

Negative

Positive

Negative

Negative

Positive

Positive

Negative

IIIA

Negative

Positive

Negative

IIIB

T0 N2 M0

T1 N2 M0

T2 N2 M0

T3 N1 M0

T3 N2 M0

G1

Positive

Positive

Positive

IIA

Negative

IIIA

Negative

Positive

Negative

Negative

Positive

Positive

IIA

Negative

IIIA

Negative

Positive

Negative

IIIB

G2

Positive

Positive

Positive

IIA

Negative

IIIA

Negative

Positive

Negative

Negative

Positive

Positive

IIA

Negative

IIIA

Negative

Positive

Negative

IIIB

G3

Positive

Positive

Positive

IIB

Negative

IIIA

Negative

Positive

Negative

Negative

Positive

Positive

Negative

IIIB

Negative

Positive

Negative

IIIC

T4 N0 M0

T4 N1 M0

T4 N2 M0

Any T N3 M0

G1

Positive

Positive

Positive

IIIA

Negative

IIIB

Negative

Positive

Negative

Negative

Positive

Positive

Negative

Negative

Positive

Negative

IIIC

G2

Positive

Positive

Positive

IIIA

Negative

IIIB

Negative

Positive

Negative

Negative

Positive

Positive

Negative

Negative

Positive

Negative

IIIC

G3

Positive

Positive

Positive

IIIB

Negative

Negative

Positive

Negative

Negative

Positive

Positive

Negative

IIIC

Negative

Positive

Negative

Any T Any N M1

Any

Any

Any

Any

IV

ER=estrogen receptor; PR=progesterone receptor

Table 8. Pathological prognostic stage (Open Table in a new window)

TNM

Grade

HER2

ER

PR

Stage

Tis N0 M0

Any

Any

Any

Any

0

T1 N0 M0

T0 N1mi M0

T1 N1mi M0

G1

Positive

Positive

Positive

IA

Negative

Negative

Positive

Negative

Negative

Positive

Positive

Negative

Negative

Positive

Negative

G2

Positive

Positive

Positive

Negative

Negative

Positive

Negative

Negative

Positive

Positive

Negative

Negative

Positive

Negative

IB

G3

Positive

Positive

Positive

IA

Negative

Negative

Positive

Negative

Negative

Positive

Positive

Negative

Negative

Positive

Negative

IB

T0 N1 M0

T1 N1 M0

T2 N0 M0

G1

Positive

Positive

Positive

IA

Negative

IB

Negative

Positive

Negative

IIA

Negative

Positive

Positive

IA

Negative

IB

Negative

Positive

Negative

IIA

G2

Positive

Positive

Positive

IA

Negative

IB

Negative

Positive

Negative

IIA

Negative

Positive

Positive

IA

Negative

IIA

Negative

Positive

Negative

G3

Positive

Positive

Positive

IA

IIA

Negative

Negative

Positive

Negative

Negative

Positive

Positive

IB

Negative

IIA

Negative

Positive

Negative

T2 N1 M0

T3 N0 M0

G1

Positive

Positive

Positive

IA

Negative

IIB

Negative

Positive

Negative

Negative

Positive

Positive

IA

Negative

IIB

Negative

Positive

Negative

G2

Positive

Positive

Positive

IB

Negative

IIB

Negative

Positive

Negative

Negative

Positive

Positive

IB

Negative

IIB

Negative

Positive

Negative

G3

Positive

Positive

Positive

IB

Negative

IIB

Negative

Positive

Negative

Negative

Positive

Positive

IIA

Negative

IIB

Negative

Positive

Negative

IIIA

T0 N2 M0

T1 N2 M0

T2 N2 M0

T3 N1 M0

T3 N2 M0

G1

Positive

Positive

Positive

IB

Negative

IIIA

Negative

Positive

Negative

Negative

Positive

Positive

IB

Negative

IIIA

Negative

Positive

Negative

G2

Positive

Positive

Positive

IB

Negative

IIIA

Negative

Positive

Negative

Negative

Positive

Positive

IB

Negative

IIIA

Negative

Positive

Negative

IIIB

G3

Positive

Positive

Positive

IIA

Negative

IIIA

Negative

Positive

Negative

Negative

Positive

Positive

IIA

Negative

IIIA

Negative

Positive

Negative

IIIC

T4 N0 M0

T4 N1 M0

T4 N2 M0

Any T N3 M0

G1

Positive

Positive

Positive

IIIA

Negative

IIIB

Negative

Positive

Negative

Negative

Positive

Positive

IIIA

Negative

IIIB

Negative

Positive

Negative

G2

Positive

Positive

Positive

IIIA

Negative

IIIB

Negative

Positive

Negative

Negative

Positive

Positive

IIIA

Negative

IIIB

Negative

Positive

Negative

IIIC

G3

Positive

Positive

Positive

IIIB

Negative

Negative

Positive

Negative

Negative

Positive

Positive

Negative

IIIC

Negative

Positive

Negative

Any T Any N M1

Any

Any

Any

Any

IV

ER=estrogen receptor; PR=progesterone receptor

 

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