Which tumor features affect treatment selection for breast cancer?

Updated: Feb 04, 2021
  • Author: Pavani Chalasani, MD, MPH; Chief Editor: John V Kiluk, MD, FACS  more...
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Breast cancers usually are epithelial tumors of ductal or lobular origin. For full discussion, see Breast Cancer Histology.

All of the following features are important in deciding on a course of treatment for any breast tumor:

  • Size
  • Status of surgical margin
  • Presence or absence of estrogen receptor (ER) and progesterone receptor (PR)
  • Nuclear and histologic grade
  • Proliferation
  • Vascular invasion
  • Tumor necrosis
  • Quantity of intraductal component
  • HER2 status

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