What are the adjuvant chemotherapy regimens used in the treatment of breast cancer?

Updated: May 21, 2019
  • Author: Erin V Newton, MD; Chief Editor: Neetu Radhakrishnan, MD  more...
  • Print
Answer

Answer

Combination chemotherapy regimens are standard recommendations in the adjuvant setting. The most commonly used regimens are shown in Table 1 below.

Table 1. Adjuvant Chemotherapy Regimens for Breast Cancer (Open Table in a new window)

Regimen

Dose and Schedule

Frequency

Cycles

TAC

T - Docetaxel (Taxotere)

75 mg/m² IV day 1

Every 21 days

6

A – Doxorubicin 

50 mg/m² IV day 1

C - Cyclophosphamide

500 mg/m² IV day 1

 

AC ⇒Taxol (T) (conventional regimen)

Doxorubicin 

60 mg/m² IV day 1

Every 21 days

4

Cyclophosphamide

600 mg/m² IV day 1

Followed by

Paclitaxel (Taxol)

175 mg/m² IV day 1

Every 21 days

4

 

Dose-dense

Doxorubicin 

60 mg/m² IV day 1

Every 14 days

4

Cyclophosphamide

600 mg/m² IV day 1

Followed by

Paclitaxel

175 mg/m² IV day 1

Every 14 days

4

 

 

 

 

Metronomic regimen

 Doxorubicin 

20 mg/m² IV day 1

Every week

12

Cyclophosphamide

50 mg/m² PO

Every day

Followed by

Paclitaxel

80 mg/m² IV day 1

Every week

12

 

AC ⇒T + H (trastuzumab [Herceptin])

Trastuzumab dosage: 4 mg/kg IV load, then 2 mg/kg weekly with paclitaxel, then give 6 mg/kg IV every 3 weeks for 40 weeks

NOTE: Trastuzumab to be added to a weekly paclitaxel regimen in HER2-positive breast cancer patients

 

FEC100

5-Fluorouracil (5-FU)

500 mg/m² IV day 1

Every 21 days

6

Epirubicin

100 mg/m² IV day 1

Cyclophosphamide

500 mg/m² IV day 1

 

FAC

5-FU

600 mg/m² IV day 1

Every 21 days

4

 Doxorubicin 

60 mg/m² IV day 1

Cyclophosphamide

600 mg/m² IV day 1

 

5-FU

500 mg/m² IV days 1 and 8

Every 28 days

6

 Doxorubicin 

30 mg/m² IV days 1 and 8

Cyclophosphamide

100 mg/m² PO days 1-14

 

CMF (Bonadonna regimen)

Cyclophosphamide

100 mg/m² PO days 1-14

Every 28 days

6

Methotrexate

40 mg/m² IV days 1 and 8

5-FU

600 mg/m² IV days 1 and 8

 

Metronomic regimen

Cyclophosphamide

50 mg/m² PO days 1-7

Weekly

24

Methotrexate

15 mg/m² IV

5-FU

300 mg/m² IV

 

TC

Taxotere (Docetaxel)

75 mg/m² IV day 1

Every 21 days

4

Cyclophosphamide

600 mg/m² IV day 1

 

TCH

Docetaxel

75 mg/m² IV day 1

Every 21 days 6

Carboplatin

AUC* 6 IV day 1

Trastuzumab

8 mg/kg loading dose IV followed by

6 mg/kg/wk q3wk

17
     
TCH-P      
Docetaxel 75 mg/m2 IV day 1 Every 21 days 6
Carboplatin AUC*6 IV day 1
Trastuzumab

8 mg/kg loading dose IV followed by

6 mg/kg 

17
Pertuzumab

840 mg loading dose IV followed by 

420 mg on subsequent doses

6
       

*AUC = systemic exposure.

References for chemotherapy regimens: TAC, [4, 5] AC => Taxol (T) (conventional regimen), [6] AC ⇒T + H (trastuzumab [Herceptin]), [7] FEC-100, [8] FAC, [9, 10] CMF (Bonadonna regimen), [11] Metronomic regimen, [12] TC, [13] TCH [14]  TCH-P 


Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!