When is neoadjuvant chemotherapy indicated in the treatment of breast cancer?

Updated: May 21, 2019
  • Author: Erin V Newton, MD; Chief Editor: Neetu Radhakrishnan, MD  more...
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Answer

Answer

The best candidates for neoadjuvant chemotherapy are patients with ER-negative and/or HER2-positive expressing tumors whose pathologically complete response (pCR) rates can approach 65% and predict long-term survival. Patients with ER-positive, HER2-negative locally advanced breast cancer (LABC) are unlikely to achieve a pCR from currently available chemotherapy.


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