Which factors are associated with moderate risk (relative risk 2.1-4.0) for breast cancer?

Updated: Dec 16, 2019
  • Author: Jessica Katz, MD, PhD, FACP; Chief Editor: Marie Catherine Lee, MD, FACS  more...
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Factors associated with RR 2.1-4.0 for breast cancer are as follows [6, 7, 8] :

  • High endogenous estrogen or testosterone level (postmenopausal)
  • First full-term pregnancy after age 35 years
  • Very dense breasts (>50%, compared with 11-25% mammographically)
  • One first-degree relative with breast cancer
  • Proliferative breast diseases (eg, atypical ductal hyperplasia)
  • Certain inherited genetic mutations (eg, CHEK2, PTEN

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