Which factors are associated with high risk (relative risk >4) for breast cancer?

Updated: Dec 16, 2019
  • Author: Jessica Katz, MD, PhD, FACP; Chief Editor: Marie Catherine Lee, MD, FACS  more...
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Factors associated with the highest risk for development of breast cancer (relative risk [RR] > 4.0) are as follows [6, 7, 8] :

  • Advanced age (65 years and older)
  • Atypical hyperplasia of breast (biopsy proven)
  • Certain inherited genetic mutations ( BRCA1, BRCA2, TP53, ATM, CDH1); RR 4-8
  • Ductal or lobular carcinoma in situ (DCIS/LCIS); RR 8-10
  • Family history of early ovarian cancer (age < 50 years)
  • Multiple first-degree relatives with breast cancer
  • Ionizing radiation exposure before age 30 (RR 22-40)
  • Personal history of early breast cancer (age < 40)

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