Which medications in the drug class Interleukin Inhibitors are used in the treatment of Psoriasis?

Updated: Nov 20, 2020
  • Author: Jacquiline Habashy, DO, MSc; Chief Editor: William D James, MD  more...
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Answer

Interleukin Inhibitors

Interleukins play key roles in the pathogenesis of plaque psoriasis.

Secukinumab (Cosentyx)

Secukinumab is a human IgG1 monoclonal antibody that selectively binds to and neutralizes the proinflammatory cytokine IL-17A. IL-17A is a naturally occurring cytokine that is involved in normal inflammatory and immune responses and plays a key role in the pathogenesis of plaque psoriasis. Following the initial once-weekly SC dosage regimen, the drug is given as a maintenance dose once monthly. It is indicated for moderate-to-severe plaque psoriasis in patients who are candidates for systemic therapy or phototherapy.

Ixekizumab (Taltz)

Ixekizumab is a humanized monoclonal IgG4 antibody that targets IL-17A and neutralizes the proinflammatory effects of IL-17A. It is administered as a SC injection. It is indicated for adults with moderate-to-severe plaque psoriasis.

Brodalumab (Siliq)

Brodalumab is a human monoclonal IgG2 antibody that selectively binds to the human IL-17A receptor and inhibits its interactions with cytokines IL-17A, IL-17F, IL-17C, IL-17A/F heterodimer, and IL-25. It is indicated for moderate-to-severe plaque psoriasis in adults who are candidates for systemic therapy or phototherapy and have failed to respond or have lost response to other systemic therapies.

Ustekinumab (Stelara)

Ustekinumab is a human monoclonal antibody directed against IL-12 and IL-23, thereby interfering with T-cell differentiation and activation and subsequent cytokine cascades. It is indicated for moderate-to-severe plaque psoriasis.

Risankizumab (Skyrizi, risankizumab-rzaa)

Risankizumab is a humanized immunoglobulin G1 (IgG1) monoclonal antibody that selectively binds to the p19 subunit of human interleukin 23 (IL-23) cytokine and inhibits its interaction with the IL-23 receptor. IL-23 is a naturally occurring cytokine that is involved in inflammatory and immune responses. It is indicated for treatment of moderate-to-severe plaque psoriasis in adults who are candidates for systemic therapy or phototherapy.

Guselkumab (Tremfya)

Guselkumab is a human monoclonal IgG1-lambda antibody that selectively binds to the p19 subunit of IL-23. IL-23 is a natural cytokine associated with inflammatory and immune responses. Guselkumab inhibits the proinflammatory actions of IL-23, thereby decreasing cytokine and chemokine release. It is indicated for adults with moderate-to-severe plaque psoriasis who are candidates for systemic therapy or phototherapy.

Tildrakizumab (Ilumya, Tildrakizumab-asmn)

This humanized IgG1/k monoclonal antibody selectively binds to the p19 subunit of IL-23 and inhibits its interaction with the IL-23 receptor. IL-23 is a natural cytokine associated with inflammatory and immune responses. Tildrakizumab inhibits the release of proinflammatory cytokines and chemokines. It is indicated for adults with moderate-to-severe plaque psoriasis who are candidates for systemic therapy or phototherapy.


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