What are the AAD-NPF joint guidelines on the use of interleukin-17 inhibitors to treat psoriasis?

Updated: Nov 20, 2020
  • Author: Jacquiline Habashy, DO, MSc; Chief Editor: William D James, MD  more...
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Answer

Interleukin-17 Inhibitors

Secukinumab recommendations are as follows:

  • Monotherapy treatment option in adults with moderate-to-severe plaque psoriasis
  • Recommended starting dose of 300 mg by self-administered SC injection at week 0, week 1, week 2, week 3, and week 4, followed by 300 mg every 4 weeks
  • Recommended maintenance dose of 300 mg every 4 weeks
  • Recommended dose of 300 mg is more effective than 150 mg
  • Can be recommended as monotherapy in adults with moderate-to-severe plaque psoriasis affecting the head and neck (including the scalp) or nails
  • Recommended as monotherapy option in adults with moderate-to-severe palmoplantar plaque psoriasis
  • Can be recommended as monotherapy option in adults with moderate-to-severe palmoplantar pustulosis
  • Can be used as monotherapy in adults with erythrodermic psoriasis
  • May be used as monotherapy in adults with plaque psoriasis when associated with psoriatic arthritis

Ixekizumab recommendations are as follows:

  • Monotherapy treatment option for adults with moderate-to-severe plaque psoriasis
  • Recommended starting dose of 160 mg by self-administered SC injection, followed by 80 mg at week 2, week 4, week 6, week 8, week 10, and week 12
  • Recommended maintenance dose of 80 mg every 4 weeks
  • Can be recommended as monotherapy option in adults with moderate-to-severe plaque psoriasis affecting the scalp or nails
  • Can be recommended as monotherapy option in adults with erythrodermic psoriasis or generalized pustular psoriasis
  • Recommended as monotherapy option in adults with plaque psoriasis when associated with psoriatic arthritis

Brodalumab recommendations are as follows:

  • Recommended as monotherapy treatment option in adults with moderate-to-severe plaque psoriasis
  • Can be used as monotherapy option in adults with generalized pustular psoriasis
  • Recommended dose of 210 mg by self-administered SC injection at week 0, week 1, and week 2, followed by 210 mg every 2 weeks

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