According to the British Association of Dermatologists guidelines, when is biologic therapy to treat psoriasis contraindicated?

Updated: Nov 20, 2020
  • Author: Jacquiline Habashy, DO, MSc; Chief Editor: William D James, MD  more...
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Answer

Contraindications for the use of biologic therapies in psoriasis patients are as follows:

  • TNF antagonist use with demyelinating diseases (and possible use of alternative therapies in those with first‐degree relatives with demyelinating disease)
  • TNF antagonist use with severe cardiac failure (New York Heart Association class III and IV)
  • Inflammatory bowel disease, which warrants gastroenterology specialist consultation before offering brodalumab, ixekizumab, or secukinumab
  • Relative contraindication in people undergoing elective surgery

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