Which medications in the drug class Antibiotic Therapy are used in the treatment of Mycoplasmal Pneumonia?

Updated: Dec 28, 2018
  • Author: Michael Joseph Bono, MD, FACEP; Chief Editor: Guy W Soo Hoo, MD, MPH  more...
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Answer

Antibiotic Therapy

Empiric antimicrobial therapy must be comprehensive and should cover all likely pathogens in the context of the clinical setting.

Erythromycin (E.E.S., Erythrocin, Ery-Tab)

Erythromycin is a macrolide antibiotic that is used in the treatment of staphylococcal and streptococcal infections. This agent acts by inhibiting bacterial growth, possibly by blocking dissociation of peptidyl tRNA from ribosomes and causing RNA-dependent protein synthesis to arrest.

Azithromycin (Zithromax)

Azithromycin is a macrolide antibiotic that is very effective against M pneumoniae and may be the most common agent used to treat M pneumoniae given its ease of administration.

Clarithromycin (Biaxin, Biaxin XL)

Clarithromycin is a macrolide antibiotic that reversibly binds to the P site of the 50S ribosomal subunit of susceptible organisms and may inhibit RNA-dependent protein synthesis by stimulating the dissociation of peptidyl tRNA from ribosomes, which results in bacterial growth inhibition.

Doxycycline (Vibramycin, Vibra-Tabs)

Doxycycline is a tetracycline antibiotic that is used to treat susceptible bacterial infections of both gram-positive and gram-negative organisms, as well as infections caused by Mycoplasma, Chlamydophilia, and Rickettsia organisms. This agent is as effective as erythromycin and other macrolides in the treatment of M pneumoniae infection. Doxycycline inhibits bacterial protein synthesis by binding with the 30S subunit and possibly the 50S ribosomal subunit of susceptible bacteria.

Levofloxacin (Levaquin)

Levofloxacin is a fluoroquinolone antibiotic that can be used to treat Mycoplasma infections. It works by inhibiting the A subunits of DNA gyrase, resulting in inhibition of bacterial DNA replication and transcription.

Moxifloxacin (Avelox)

Moxifloxacin is a fluoroquinolone antibiotic that inhibits the A subunits of DNA gyrase, resulting in inhibition of bacterial DNA replication and transcription.


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