What is the efficacy of a combined treatment approach to thymoma?

Updated: Dec 03, 2018
  • Author: Kendrix J Evans, MD, MS; Chief Editor: John Geibel, MD, MSc, DSc, AGAF  more...
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Answer

A multidisciplinary approach to therapy for unresectable thymomas has been advocated. [10, 11] In a trial conducted by the M.D. Anderson Cancer Center, 12 patients received a treatment regimen consisting of induction chemotherapy (ie, three courses of cyclophosphamide, doxorubicin, cisplatin, and prednisone), surgical resection, postoperative radiation therapy, and consolidation chemotherapy (ie, three courses of cyclophosphamide, doxorubicin, cisplatin, and prednisone). [12]

Of the 12 patients, three (25%) had a complete response, eight (67%) a partial response, and one (8%) a minor response. [12] One patient refused surgery, nine (82%) had complete resections, and two (18%) who had been receiving radiation therapy and consolidation chemotherapy had incomplete resections. All 12 patients (100%) were alive at 7 years, and 10 (73%) were disease-free at 7 years. The authors suggested that aggressive multimodal treatment is effective and may be curative in locally advanced, unresectable, malignant thymomas.


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