What is the role of medications in the treatment of splenic infarct?

Updated: Jul 27, 2020
  • Author: Manish Parikh, MD; Chief Editor: John Geibel, MD, MSc, DSc, AGAF  more...
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Surgery is indicated only in the presence of complications. Otherwise, the infarcted spleen can be left in situ, and the patient can be observed. Because of the rarity of this disorder and the largely anecdotal character of many reports, the roles of antibiotics and antiplatelet agents (for the treatment of thrombocytosis) have not been formally addressed. Similarly, no scientifically supported information exists regarding the possible increase in susceptibility to overwhelming postsplenectomy sepsis (OPSS) in these patients.

The principal mainstay of nonoperative therapy is analgesia with either narcotics or nonsteroidal anti-inflammatory drugs (NSAIDs) and close follow-up. Many of the altitude-related episodes in patients with sickle cell disease can be safely treated with supportive care rather than with splenectomy. [3] In certain circumstances, isolated splenic abscess can be treated with percutaneous drainage alone, and splenectomy can be avoided. However, a patient with multiple splenic abscesses usually will require splenectomy.

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