What causes splenic infarct?

Updated: Jul 27, 2020
  • Author: Manish Parikh, MD; Chief Editor: John Geibel, MD, MSc, DSc, AGAF  more...
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Another mechanical cause of splenic infarct can be the injection of gastric varices in the setting of portal hypertension and gastric variceal bleeding. [7]

Hypercoagulable states can cause splenic infarction. For instance, hereditary protein C deficiency has been reported to cause splenic infarction. [8] Acquired hypercoagulable states include myeloproliferative disorders, lupus anticoagulant, and erythropoietin therapy.

Splenic infarct has also been reported in association with postpartum toxic shock syndrome. [9]

Splenic vein thrombosis, most commonly the result of pancreatitis or surgery, can result in venous infarction.

Unusual causes of splenic infarction include malaria, [10] pancreatitis, and cocaine use; it can also occur, uncommonly, as a late complication of liver transplantation.

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