Which medications in the drug class Tricyclic Antidepressant Medications are used in the treatment of Diabetic Lumbosacral Plexopathy?

Updated: Jan 04, 2021
  • Author: Divakara Kedlaya, MBBS; Chief Editor: Milton J Klein, DO, MBA  more...
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Tricyclic Antidepressant Medications

These drugs have central and peripheral anticholinergic effects, as well as sedative effects, and block the active reuptake of norepinephrine and serotonin.


Amitriptyline is an oral analgesic for certain types of chronic pain. The usual adult dose ranges from 30-150 mg/d.

Nortriptyline (Pamelor)

Nortriptyline has demonstrated effectiveness in the treatment of chronic pain via inhibition of the reuptake of serotonin and/or norepinephrine by the presynaptic neuronal membrane. As a result, this drug increases the synaptic concentration of these neurotransmitters in the central nervous system (CNS). In addition, pharmacodynamic effects, such as the desensitization of adenyl cyclase and the down-regulation of beta-adrenergic receptors and serotonin receptors, appear to play a role in its mechanisms of action.

Doxepin (Silenor)

This agent inhibits histamine and acetylcholine activity and has proven useful in the treatment of various forms of depression associated with chronic and neuropathic pain.

Desipramine (Norpramin)

Desipramine may increase the synaptic concentration of norepinephrine in the CNS by inhibiting reuptake by presynaptic neuronal membrane. The drug may have effects in the desensitization of adenyl cyclase and in the downregulation of beta-adrenergic receptors and serotonin receptors.

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